![RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer](https://files.rcsb.org/pub/pdb/validation_reports/kj/5kj2/5kj2_multipercentile_validation.png)
RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer
![Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife](https://iiif.elifesciences.org/lax/63512%2Felife-63512-fig3-v3.tif/full/1500,/0/default.jpg)
Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife
![Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41419-020-02960-6/MediaObjects/41419_2020_2960_Fig7_HTML.png)
Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease
![A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram](https://www.researchgate.net/profile/Peter-De-Vries-6/publication/320066101/figure/fig4/AS:651239113125889@1532278912950/A-485-inhibits-AR-activity-in-prostate-cancer_Q320.jpg)
A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram
![A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram](https://www.researchgate.net/publication/320066101/figure/fig3/AS:651239113117697@1532278912302/A-485-potently-inhibits-p300-CBP-in-cells-a-Analysis-of-high-content-microscopy-shows.png)
A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram
![A-485 potently inhibits p300/CBP in vitro (a) Chemical structures of... | Download Scientific Diagram A-485 potently inhibits p300/CBP in vitro (a) Chemical structures of... | Download Scientific Diagram](https://www.researchgate.net/publication/320066101/figure/fig1/AS:651239108902912@1532278911008/A-485-potently-inhibits-p300-CBP-in-vitro-a-Chemical-structures-of-screening-hits.png)
A-485 potently inhibits p300/CBP in vitro (a) Chemical structures of... | Download Scientific Diagram
![CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation | Epigenetics & Chromatin | Full Text CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation | Epigenetics & Chromatin | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13072-018-0197-x/MediaObjects/13072_2018_197_Fig7_HTML.png)
CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation | Epigenetics & Chromatin | Full Text
![A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram](https://www.researchgate.net/profile/Peter-De-Vries-6/publication/320066101/figure/fig3/AS:651239113117697@1532278912302/A-485-potently-inhibits-p300-CBP-in-cells-a-Analysis-of-high-content-microscopy-shows_Q320.jpg)
A-485 potently inhibits p300/CBP in cells (a) Analysis of high content... | Download Scientific Diagram
![Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41419-020-02960-6/MediaObjects/41419_2020_2960_Fig3_HTML.png)
Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis | Cell Death & Disease
![A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL - ScienceDirect A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295220301428-ga1.jpg)
A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL - ScienceDirect
![Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife](https://iiif.elifesciences.org/lax/63512%2Felife-63512-fig4-v3.tif/full/1500,/0/default.jpg)
Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition | eLife
![p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization](https://www.thno.org/v09/p8344/thnov09p8344g002.jpg)
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
![RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer](https://cdn.rcsb.org/images/structures/5kj2_assembly-1.jpeg)
RCSB PDB - 5KJ2: The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer
![p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization](https://www.thno.org/v09/p8344/thnov09p8344g001.jpg)
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
![p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss - ScienceDirect p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1567576921000941-gr1.jpg)
p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss - ScienceDirect
![A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL - ScienceDirect A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295220301428-gr6.jpg)